Assessment of maximum inspiratory pressure: Prior submaximal respiratory muscle activity (‘warm-up’) enhances maximum inspiratory activity and attenuates the learning effect of repeated measurement

The official published version can be obtained from the link belowBackground: The variability of maximal inspiratory pressure (PImax) in response to repeated measurement affects its reliability; published studies have used between three and twenty PImax measurements on a single occasion. Objective: This study investigated the influence of a specific respiratory ‘warm-up’ upon the repeated measurement of inspiratory muscle strength and attempts to establish a procedure by which PImax can be assessed with maximum reliability using the smallest number of manoeuvres. Methods: Fourteen healthy subjects, familiar with the Mueller manoeuvre, were studied. The influence of repeated testing on a single occasion was assessed using an 18-measurement protocol. Using a randomised cross-over design, subjects performed the protocol, preceded by a specific respiratory warm-up (RWU) and on another occasion, without any preliminary activity (control). Comparisons were made amongst ‘baseline’ (best of the first 3 measurements), ‘short’ series (best of 7th to 9th measurement) and ‘long’ series (best of the last 3 measurements). Results: Under control conditions, the mean increase (‘baseline’ vs. ‘long’ series) was 11.4 (5.8)%; following the RWU, the increase (post RWU ‘baseline’ vs. ‘long’ series) was 3.2 (10.0)%. There were statistically significant differences between measurements made at all 3 protocol stages (‘baseline’, ‘short’ and ‘long’ series) under control conditions, but none following the RWU. Conclusions: The present data suggest that a specific RWU may attenuate the ‘learning effect’ during repeated PImax measurements, which is one of the main contributors of the test variability. The use of a RWU may provide a means of obtaining reliable values of PImax following just 3 measurements.This work was partially supported by a grant from the University of Wolverhampton, UK

GRAPE - A Balloon-Borne Gamma-Ray Polarimeter Experiment

This paper reviews the development status of GRAPE (the Gamma-Ray Polarimeter Experiment), a hard X-ray Compton Polarimeter. The purpose of GRAPE is to measure the polarization of hard X-rays in the 50-300 keV energy range. We are particularly interested in X-rays that are emitted from solar flares and gamma-ray bursts (GRBs), although GRAPE could also be employed in the study of other astrophysical sources. Accurately measuring the polarization of the emitted radiation will lead to a better understating of both emission mechanisms and source geometries. The GRAPE design consists of an array of plastic scintillators surrounding a central high-Z crystal scintillator. The azimuthal distribution of photon scatters from the plastic array into the central calorimeter provides a measure of the polarization fraction and polarization angle of the incident radiation. The design of the detector provides sensitivity over a large field-of-view (>pi steradian). The design facilitates the fabrication of large area arrays with minimal deadspace. This paper presents the latest design concept and the most recent results from laboratory tests of a GRAPE science model.Comment: 6 pages; paper presented at the FRASCATI Workshop 2005 on Multifrequency Behaviour of High Energy Cosmic Sources; submitted to Chinese Journal of Astronomy and Astrophysic

The 2000 Periastron Passage of PSR B1259-63

We report here on a sequence of 28 observations of the binary pulsar system PSR B1259-63/SS2883 at four radio frequencies made with the Australia Telescope Compact Array around the time of the 2000 periastron passage. Observations made on 2000 Sep 1 show that the pulsar's apparent rotation measure (RM) reached a maximum of $-14800 \pm 1800$ rad m$^{-2}$, some 700 times the value measured away from periastron, and is the largest astrophysical RM measured. This value, combined with the dispersion measure implies a magnetic field in the Be star's wind of 6 mG. We find that the light curve of the unpulsed emission is similar to that obtained during the 1997 periastron but that differences in detail imply that the emission disc of the Be star is thicker and/or of higher density. The behaviour of the light curve at late times is best modelled by the adiabatic expansion of a synchrotron bubble formed in the pulsar/disc interaction. The expansion rate of the bubble $\sim 12$ km s$^{-1}$ is surprisingly low but the derived magnetic field of 1.6 G close to that expected.Comment: 8 pages, 6 figures, 3 tables, LaTeX (mn.sty). Accepted for publication in the Monthly Notices of the Royal Astronomical Society. Also available at http://astronomy.swin.edu.au/staff/tconnors/publications.htm

Polarized Diffuse Emission at 2.3 GHz in a High Galactic Latitude Area

Polarized diffuse emission observations at 2.3 GHz in a high Galactic latitude area are presented. The 2\degr X 2\degr field, centred in (\alpha=5^h,\delta=-49\degr), is located in the region observed by the BOOMERanG experiment. Our observations has been carried out with the Parkes Radio telescope and represent the highest frequency detection done to date in low emission areas. Because of a weaker Faraday rotation action, the high frequency allows an estimate of the Galactic synchrotron contamination of the Cosmic Microwave Background Polarization (CMBP) that is more reliable than that done at 1.4 GHz. We find that the angular power spectra of the E- and B-modes have slopes of \beta_E = -1.46 +/- 0.14 and \beta_B = -1.87 +/- 0.22, indicating a flattening with respect to 1.4 GHz. Extrapolated up to 32 GHz, the E-mode spectrum is about 3 orders of magnitude lower than that of the CMBP, allowing a clean detection even at this frequency. The best improvement concerns the B-mode, for which our single-dish observations provide the first estimate of the contamination on angular scales close to the CMBP peak (about 2 degrees). We find that the CMBP B-mode should be stronger than synchrotron contamination at 90 GHz for models with T/S > 0.01. This low level could move down to 60-70 GHz the optimal window for CMBP measures.Comment: 5 pages, 6 figures, accepted for publication in MNRAS Letter

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation

We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells. By itself it induced a modest degree of B cell proliferation, but together with anti-immunoglobulin (anti-Ig) antibody it greatly stimulated B cell proliferation, as determined by both [3H]thymidine uptake and increase in cell numbers. These data are evidence that the CD40 ligand on T cells provides a signal that drives B cell proliferation. This signal is synergistic with that delivered by anti-Ig antibody

SONTRAC—a scintillating plastic fiber tracking detector for neutron and proton imaging spectroscopy

SONTRAC (SOlar Neutron TRACking imager and spectrometer) is a conceptual instrument intended to measure the energy and incident direction of 20–150 MeV neutrons produced in solar flares. The intense neutron background in a low-Earth orbit requires that imaging techniques be employed to maximize an instrument’s signal-to-noise ratio. The instrument is comprised of mutually perpendicular, alternating layers of parallel, scintillating, plastic fibers that are viewed by optoelectronic devices. Two stereoscopic views of recoil proton tracks are necessary to determine the incident neutron’s direction and energy. The instrument can also be used as a powerful energetic proton imager. Data from a fully functional 3-d prototype are presented. Early results indicate that the instrument’s neutron energy resolution is approximately 10% with the neutron incident direction determined to within a few degrees

Gas micro-well track imaging detectors for gamma-ray astronomy

We describe our program to develop gas micro-well detectors (MWDs) as three-dimensional charged particle trackers for use in advanced gamma-ray telescope concepts. A micro-well detector consists of an array of individual micro-patterned gas proportional counters opposite a planar drift electrode. The well anodes and cathodes may be connected in X and Y strips, respectively, to provide two-dimensional imaging. When combined with transient digitizer electronics, which record the time signature of the charge collected in the wells of each strip, full three-dimensional reconstruction of charged-particle tracks in large gas volumes is possible. Such detectors hold great promise for advanced Compton telescope (ACT) and advanced pair telescope (APT) concepts due to the very precise measurement of charged particle momenta that is possible (Compton recoil electrons and electron-positron pairs, respectively). We present preliminary lab results, including detector fabrication, prototype electronics, and initial detector testing. We also discuss applications to the ACT and APT mission concepts, based on GEANT3 and GEANT4 simulations